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Mushtaq Bilal, PhDResearcher @ Syddansk Universitet
Mushtaq Bilal, PhDResearcher @ Syddansk UniversitetLoved by 1 million+ researchers from
Popular papers to read
Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer
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Top papers of 2023
Data from Plasma Thymidine Kinase Activity as a Biomarker in Patients with Luminal Metastatic Breast Cancer Treated with Palbociclib within the TREnd Trial
31 Mar 2023
In this paper , the authors explored TK1 as a biomarker of palbociclib response, both in vitro and in patients with advanced breast cancer (ABC) in patients enrolled in the To Reverse Endocrine Resistance (TREnd) trial.Data from The Immune Microenvironment and Neoantigen Landscape of Aggressive Salivary Gland Carcinomas Differ by Subtype
31 Mar 2023
In this article , the authors performed RNA sequencing (RNA-seq) in 76 tumors representing the three most lethal histologies: adenoid cystic carcinoma (ACC), myoepithelial carcinoma, and salivary duct carcinomas (SDC).Data from Dietary Fat Intake During Adolescence and Breast Density Among Young Women
31 Mar 2023
In this paper , the authors examined associations between adolescent fat intake and breast density and calculated geometric mean and 95% confidence intervals for MRI-measured breast density at ages 25-29 years across quartiles of fat intake using linear mixed-effect regression.Data from Oncolytic HSV–Infected Glioma Cells Activate NOTCH in Adjacent Tumor Cells Sensitizing Tumors to Gamma Secretase Inhibition
31 Mar 2023
In this paper , the effect of oncolytic herpes simplex virus (oHSV) on NOTCH signaling in central nervous system tumors was examined and the significance of combining oHSV and gamma secretase inhibitor (GSI) for glioblastoma therapy was highlighted.Data from Entospletinib in Combination with Induction Chemotherapy in Previously Untreated Acute Myeloid Leukemia: Response and Predictive Significance of <i>HOXA9</i> and <i>MEIS1</i> Expression
31 Mar 2023
In this paper , the safety and efficacy of entospletinib, a selective inhibitor of SYK, in combination with chemotherapy in untreated acute myeloid leukemia (AML) were evaluated.Data from Exosome-Transmitted <i>PSMA3</i> and <i>PSMA3-AS1</i> Promote Proteasome Inhibitor Resistance in Multiple Myeloma
31 Mar 2023
In this paper , the role of exosomal RNAs in PI sensitivity was evaluated and by which molecular mechanisms they exert this function in mesenchymal stem cells (MSC) to multiple myeloma cells.Data from lncRNA <i>THAP9-AS1</i> Promotes Pancreatic Ductal Adenocarcinoma Growth and Leads to a Poor Clinical Outcome via Sponging miR-484 and Interacting with YAP
31 Mar 2023
Wang et al. as discussed by the authors investigated the roles and mechanisms of long noncoding RNAs (lncRNA) in pancreatic ductal adenocarcinoma (PDAC).Data from Phase Ib Clinical Trial of IGV-001 for Patients with Newly Diagnosed Glioblastoma
31 Mar 2023
In this paper , the authors evaluated IGV-001, which combines autologous glioblastoma tumor cells and an antisense oligonucleotide against IGF type 1 receptor (IMV-1), in newly diagnosed brain cancer patients.Data from Inotuzumab Ozogamicin for Relapsed/Refractory Acute Lymphoblastic Leukemia in the INO-VATE Trial: CD22 Pharmacodynamics, Efficacy, and Safety by Baseline CD22
31 Mar 2023
In this article , the relationship between cluster of differentiation-22 (CD22) expression and outcomes of inotuzumab ozogamicin versus standard of care (SC) was assessed.Data from Proliferation and AKT Activity Biomarker Analyses after Capivasertib (AZD5363) Treatment of Patients with ER<sup>+</sup> Invasive Breast Cancer (STAKT)
31 Mar 2023
The STAKT study as mentioned in this paper examined short-term exposure (4.5 days) to the oral selective pan-AKT inhibitor capivasertib (AZD5363) to determine if this drug can reach its therapeutic target in sufficient concentration to significantly modulate key biomarkers of the AKT pathway and tumor proliferation.Data from Whole-Slide Image Analysis Reveals Quantitative Landscape of Tumor–Immune Microenvironment in Colorectal Cancers
31 Mar 2023
In this article , an open-source software-based analytic pipeline for quantifying tumor-infiltrating lymphocytes (TIL) and tumor-stroma ratio (TSR) from whole-slide images obtained after CD3 and CD8 IHC staining is presented.Data from A Diagnostic Biopsy-Adapted Immunoscore Predicts Response to Neoadjuvant Treatment and Selects Patients with Rectal Cancer Eligible for a Watch-and-Wait Strategy
31 Mar 2023
In this paper , a diagnostic biopsy-adapted immunoscore (IS<sub>B<,/p&t;/sub&g;) could predict response to neoadjuvant treatment (nT) and better define patients eligible to an organ preservation strategy (watch-and-wait) in locally advanced rectal cancer (LARC).Data from Deep Learning for Fully Automated Prediction of Overall Survival in Patients with Oropharyngeal Cancer Using FDG-PET Imaging
31 Mar 2023
In this paper , the authors developed an objective and robust deep learning-based fully-automated tool called the DeepPET-OPSCC biomarker for predicting overall survival (OS) in oropharyngeal squamous cell carcinoma (OPSCC) using FDG-PET imaging.Data from MRI and <sup>18</sup>FET-PET Predict Survival Benefit from Bevacizumab Plus Radiotherapy in Patients with Isocitrate Dehydrogenase Wild-type Glioblastoma: Results from the Randomized ARTE Trial
31 Mar 2023
In this paper , the authors explored the role of MRI and O-(2)-L-tyrosine PET parameters for outcome in the randomized multicenter trial ARTE that compared bevacizumab plus radiotherapy with radiotherpay alone in elderly patients with glioblastoma.Data from The FDA Oncology Center of Excellence Scientific Collaborative: Charting a Course for Applied Regulatory Science Research in Oncology
31 Mar 2023
The FDA Oncology Center of Excellence (OCE) identified nine scientific priority areas and one cross-cutting area of high interest for collaboration with external researchers and highlighted funded and unfunded opportunities for external researchers to work with FDA staff on critical regulatory science challenges as mentioned in this paper .Data from Spatial Mapping and Immunomodulatory Role of the OX40/OX40L Pathway in Human Non–Small Cell Lung Cancer
31 Mar 2023
In this paper , the authors evaluated the tissue distribution and clinical significance of the OX40 pathway in human non-small cell lung cancer (NSCLC) using multiplexed quantitative immunofluorescence.Data from Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer
31 Mar 2023
In this article , the authors exploited biological pathway analyses in a patient-derived xenograft (PDX) trial to study Regorafenib (REG) response mechanisms and elucidate putative biomarkers.Data from Association of <i>NOS3</i> and <i>ANGPT2</i> Gene Polymorphisms with Survival in Patients with Hepatocellular Carcinoma Receiving Sorafenib: Results of the Multicenter Prospective INNOVATE Study
31 Mar 2023
The multicenter INNOVATE study as mentioned in this paper validated the role of nitric oxide synthase in patients with hepatocellular carcinoma (HCC) treated with sorafenib.Data from Phase I Study of Lysine-Specific Demethylase 1 Inhibitor, CC-90011, in Patients with Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma
31 Mar 2023
CC-90011-ST-001 (NCT02875223; 2015-005243-13) is a phase I, multicenter, first-inhuman dose-escalation study as discussed by the authors .Data from Functional Mapping of AKT Signaling and Biomarkers of Response from the FAIRLANE Trial of Neoadjuvant Ipatasertib plus Paclitaxel for Triple-Negative Breast Cancer
31 Mar 2023
In this paper , the authors used reverse-phase protein microarrays (RPPA) to examine the total level and/or phosphorylation states of over 100 proteins in various signaling or cell processes including PI3K/AKT and mTOR signaling.Data from Predictable Clinical Benefits without Evidence of Synergy in Trials of Combination Therapies with Immune-Checkpoint Inhibitors
31 Mar 2023
In this paper , the authors analyzed 13 phase III clinical trials testing combinations of ICIs with each other or other drugs in patients with advanced melanoma and lung, breast, gastric, kidney, and head and neck cancers.Data from Dual Targeting of CDK and Tropomyosin Receptor Kinase Families by the Oral Inhibitor PHA-848125, an Agent with Broad-Spectrum Antitumor Efficacy
31 Mar 2023
PHA-848125 as discussed by the authors is a dual inhibitor of cyclin-dependent kinase and tropomyosin receptor kinase (TRK) that possesses significant antitumor activity.Data from Bioactivation of Napabucasin Triggers Reactive Oxygen Species–Mediated Cancer Cell Death
31 Mar 2023
In this paper , a small molecule called Napabucasin (2-acetylfuro-1,4-naphthoquinone or BBI-608) is used to inhibit STAT3 signaling.Data from <i>In vivo</i> target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies
31 Mar 2023
In this paper , the authors developed a molecular imaging probe consisting of multiple self-quenching fluorophores conjugated to a monoclonal antibody (trastuzumab) to synthesize Tra-Cy5.5 or Alexa Fluor 680 (Alexa680) conjugates, respectively.Data from Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian Cancer
31 Mar 2023
Aldehyde dehydrogenase-1A1 (ALDH 1A1) expression characterizes a subpopulation of cells with tumor-initiating or cancer stem cell properties in several malignancies as discussed by the authors .Data from Doxorubicin Resistance in a Novel <i>In vitro</i> Model of Human Pleomorphic Liposarcoma Associated with Alternative Lengthening of Telomeres
31 Mar 2023
In this article , the authors used the alternative lengthening of telomeres (ALT) mechanism to modulate the response of human pleomorphic liposarcoma to DNA-damaging agents.Data from Randomized Phase II Trial of Anthracycline-free and Anthracycline-containing Neoadjuvant Carboplatin Chemotherapy Regimens in Stage I–III Triple-negative Breast Cancer (NeoSTOP)
31 Mar 2023
The NeoSTOP multisite randomized phase II trial as discussed by the authors was designed to assess the efficacy of anthracycline-free and carboplatin-containing neoadjuvant regimens.Data from Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer
31 Mar 2023
In this article , the expression and activation of receptor tyrosine kinases were evaluated in response to combined MEK and AKT inhibition in KPC mice and pancreatic ductal organoids.Data from The Integrin Inhibitor Cilengitide Affects Meningioma Cell Motility and Invasion
31 Mar 2023
In this paper , integrin expression in tissue microarrays of human meningiomas and the antimeningioma properties of cilengitide in cell cultures, subcutaneous and intracranial nude mouse models by measuring tumor volumes and survival times.Data from <i>FGFR1</i> Amplification Mediates Endocrine Resistance but Retains TORC Sensitivity in Metastatic Hormone Receptor–Positive (HR<sup>+</sup>) Breast Cancer
31 Mar 2023
In this paper , the authors evaluated clinical response to endocrine and targeted therapies in a cohort of patients with metastatic breast cancer (MBC) and validated the functional role of FGFR1 amplification in mediating response/resistance to hormone therapy.Data from Tumor Mutational Burden, Toxicity, and Response of Immune Checkpoint Inhibitors Targeting PD(L)1, CTLA-4, and Combination: A Meta-regression Analysis
31 Mar 2023
In this paper , the authors investigated the relationship between mutational burden (TMB) and clinical response to ICI therapy across multiple cancer types and found that TMB was associated with ORR for anti-PD(L)1, anti-CTLA-4, and combination ICI.Data from Phase I Study of the Efficacy and Safety of Ramucirumab in Combination with Osimertinib in Advanced T790M-positive <i>EGFR</i>-mutant Non–small Cell Lung Cancer
31 Mar 2023
In this paper , the combination of the EGFR tyrosine kinase inhibitor (TKI) osimertinib plus the VEGFR2-directed antibody ramucirumab was evaluated in patients with T790M-positive non-small cell lung cancer (NSCLC).Data from FDA Approval Summary: Tisagenlecleucel for Treatment of Patients with Relapsed or Refractory B-cell Precursor Acute Lymphoblastic Leukemia
31 Mar 2023
Tisagenlecleucel (Kymriah; Novartis Pharmaceuticals) is a CD19-directed genetically modified autologous T-cell immunotherapy as discussed by the authors .Data from Prognostic Impact of Natural Killer Cell Count in Follicular Lymphoma and Diffuse Large B-cell Lymphoma Patients Treated with Immunochemotherapy
31 Mar 2023
In this article , the authors assessed whether low pretreatment NK-cell count (NKCC) in peripheral blood or tumor tissue was associated with worse outcome in patients receiving antibody-based therapy and found that low-prereatment NK cells are key effector cells for anti-CD20 monoclonal antibodies (mAb), such as obinutuzumab and rituximab.Data from How to Train Your T Cells: Overcoming Immune Dysfunction in Multiple Myeloma
31 Mar 2023
A review of T-cell-associated changes during the evolution of multiple myeloma and an overview of Tcell-dependent immuno-oncology approaches under investigation can be found in this paper .Data from Postablation Modulation after Single High-Dose Radiation Therapy Improves Tumor Control via Enhanced Immunomodulation
31 Mar 2023
In this article , a novel immunological basis for radiation dose fractionation consisting of a single high-dose radiotherapy, followed by postablation modulation (PAM) with four daily low-dose fractions (22 Gy + 0.5 Gy × 4) was provided.Data from A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory <i>BRAF</i> V600 Mutation–Positive Solid Tumors
31 Mar 2023
The phase I/IIa, open-label study (NCT01677741) as discussed by the authors sought to determine the safety, tolerability, pharmacokinetics, and preliminary activity of dabrafenib in pediatric patients with advanced V600-mutated cancers.Data from Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial
31 Mar 2023
In this article , the concordance between tumor DNA (tDNA) and cfDNA analysis on a large cohort of patients with advanced or metastatic solid tumor, eligible for phase I trial and with good performance status, enrolled in MOSCATO 01 trial (clinical trial NCT01566019).Data from ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer
31 Mar 2023
In this paper , a novel TGFβ1/ERK/PHD2-mediated pathway regulating HIF1α stability in ovarian cancer was discovered, and the combination efficacy of inhibitors of HIF 1α (YC-1), ERK (selumetinib), and TGF β1 (SB431542) with platinum drugs was evaluated.Data from Nivolumab in Patients with Advanced Platinum-resistant Urothelial Carcinoma: Efficacy, Safety, and Biomarker Analyses with Extended Follow-up from CheckMate 275
31 Mar 2023
In this article , the authors report efficacy and safety with extended follow-up, and exploratory biomarker analyses from the phase II CheckMate 275 trial to identify biomarkers of response to nivolumab in platinum-resistant metastatic or unresectable urothelial carcinoma (mUC).Data from The IGF2/IR/IGF1R Pathway in Tumor Cells and Myofibroblasts Mediates Resistance to EGFR Inhibition in Cholangiocarcinoma
31 Mar 2023
In this paper , the authors investigated resistance mechanisms against EGFR inhibition in cholangiocarcinoma (CCA) cells and found that resistant cells exhibited an upregulation of insulin receptor (IR) and insulin-like growth factor (IGF) 1 receptor, along with an increase in IGF2 expression.Data from Submucosal Saline Injection Followed by Endoscopic Ultrasound versus Endoscopic Ultrasound Only for Distinguishing between T1a and T1b Esophageal Cancer
31 Mar 2023
Wang et al. as mentioned in this paper examined whether submucosal saline injection (SSI) can improve traditional endoscopic ultrasound (EUS) accuracy in distinguishing between T1a and T1b stage esophageal squamous cell carcinoma (ESCC).Data from Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non–Small Cell Lung Cancer
31 Mar 2023
In this article , the authors identify an MTD of olaparib, a PARP inhibitor, in combination with loco-regional radiotherapy with/without cisplatin for the treatment of non-small cell lung cancer (NSCLC).Data from Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L1 Expression on Response to Therapy
31 Mar 2023
In this article , an autologous heat-shock protein vaccine (Prophage) was used to improve the survival of newly diagnosed glioblastoma (GBM) patients.Data from Clinical Significance of Four Molecular Subtypes of Gastric Cancer Identified by The Cancer Genome Atlas Project
31 Mar 2023
The Cancer Genome Atlas (TCGA) project recently uncovered four molecular subtypes of gastric cancer: Epstein-Barr virus (EBV), microsatellite instability (MSI), genomically stable (GS), and chromosomal instability (CIN) as discussed by the authors .Data from The Interleukin 22 Pathway Interacts with Mutant KRAS to Promote Poor Prognosis in Colon Cancer
31 Mar 2023
In this article , the IL22 pathway is associated with prognosis in human colorectal cancer, and to identify mechanisms by which IL22 can influence disease progression, but the clinical significance of IL22 in human colon cancer remains unclear.Data from Heterogeneity in <i>NECTIN4</i> Expression Across Molecular Subtypes of Urothelial Cancer Mediates Sensitivity to Enfortumab Vedotin
31 Mar 2023
In this paper , the authors examined heterogeneity of gene expression across molecular subtypes of bladder cancer and determined whether NECTIN4 expression mediates EV sensitivity or resistance in urothelial bladder cancer cells.Data from Transcriptomic Profiling Identifies a Risk Stratification Signature for Predicting Peritoneal Recurrence and Micrometastasis in Gastric Cancer
31 Mar 2023
In this article , the authors performed a systematic discovery and validation for the identification of peritoneal recurrence prediction by analyzing expression profiling datasets from 249 patients with gastric cancer, followed by analysis of 426 patients from three cohorts for clinical validation.Top papers of 2022
Oral exposure to polyethylene microplastics alters gut morphology, immune response, and microbiota composition in mice.
01 Apr 2022 - Environmental research
In this article , the effects of intestinal exposure to polyethylene microplastic microbeads on gut homeostasis were investigated in mice, and the most marked deleterious effects were found in co-exposed mice.Numerical simulation of downwash airflow distribution inside tree canopies of an apple orchard from a multirotor unmanned aerial vehicle (UAV) sprayer
01 Apr 2022 - Computers and Electronics in Agriculture
In this paper , a CFD model for predicting downwash airflow inside tree canopies was developed using computational fluid dynamics (CFD) for UAV spraying in orchards.Adenomatous Polyposis Coli (APC) in cell migration.
01 Apr 2022 - European Journal of Cell Biology
In this paper , the authors review available information about roles of Adenomatous Polyposis Coli (APC) in cell migration and propose a model explaining how microtubules, using APC as an intermediate, can initiate leading edge protrusion in response to external signals by stimulating Arp2/3 complex-dependent nucleation of branched actin filament networks via a series of intermediate events.Effectiveness and Cost-effectiveness of an Empowerment-Based Self-care Education Program on Health Outcomes Among Patients With Heart Failure
01 Apr 2022 - JAMA network open
It is suggested that education using an empowerment approach is more effective than didactic methods to improve self-care and health outcomes of patients with heart failure.Gated recurrent unit least-squares generative adversarial network for battery cycle life prediction
01 Apr 2022 - Measurement
In this paper , a least-squares generative adversarial network with the gated recurrent unit as the generator and multi-layer perceptron as the discriminator is used to predict the remaining useful life of lithium-ion batteries.Generic Constructions of (Boolean and Vectorial) Bent Functions and Their Consequences
01 Apr 2022 - IEEE Transactions on Information Theory
This article provides several new infinite families of bent functions, including idempotent bent functions of any algebraic degree, bent functions in univariate trace form, and self-dual bent functions.An adult-stage transcriptional program for survival of serotonergic connectivity
01 Apr 2022 - Cell Reports
Guedes-Dias et al. as mentioned in this paper found that the adult-stage deficiency of Lmx1b and Pet1 causes slowly progressing degeneration of 5-HT synapses and axons, increased susceptibility of 5HT axons to neurotoxic injury, and abnormal stress responses.COVID-19 effects on urban driving, walking, and transit usage trends: Evidence from Indian metropolitan cities
01 Apr 2022 - Cities
In this paper , a comparative analysis of the changes in usage of different mobility modes during the national lockdown and unlock policy periods across 6 Indian cities (Bangalore, Chennai, Delhi, Hyderabad, Mumbai, and Pune) explain the spatio-temporal differences in mode usages.Adversarial attacks and defenses in Speaker Recognition Systems: A survey
01 Apr 2022 - Journal of Systems Architecture
In this paper , a comprehensive survey on adversarial attacks and defenses in speaker recognition systems is presented, and two sets of criteria to evaluate the performance of attack methods and defense methods in SRSs, respectively.pH-controlled reversible deep-eutectic solvent based enzyme system for simultaneous extraction and in-situ separation of isoflavones from Pueraria lobata
01 Apr 2022 - Separation and Purification Technology
In this article , a pH controlled reversible deep-eutectic solvents (DESs) based enzyme system was developed for efficient extraction, transformation and in-situ separation of natural products from herbs.Recent advances in analytical strategies for coffee volatile studies: Opportunities and challenges.
01 Apr 2022 - Food Chemistry
In this article , the benefits of state-of-the-art analytical techniques applied to coffee volatile analysis from experimental design to sample preparation, separation, detection, and data analysis are evaluated.Relationship between Drug Holidays of Antiresorptive Agents and Surgical Outcomes in Cancer Patients with Medication-Related Osteonecrosis of the Jaw
01 Apr 2022 - International Journal of Environmental Research and Public Health
Investigating whether a drug holiday promoted sequestrum separation and improved the surgical outcomes of MRONJ patients with malignant tumors, who were undergoing high-dose AR therapy found that drug holidays of 60, 90, and 120 days did not influence patients’ surgical outcomes.Early Trauma-Focused Counseling for the Prevention of Acute Coronary Syndrome-Induced Posttraumatic Stress: Social and Health Care Resources Matter
01 Apr 2022 - Stomatology
Early psychological intervention after ACS with a trauma-focused approach to prevent the development of PTSD symptoms may be beneficial for patients who perceive high social support or participate in CR for several weeks.MiRKAT-MC: A Distance-Based Microbiome Kernel Association Test With Multi-Categorical Outcomes
01 Apr 2022 - Frontiers in Genetics
A microbiome kernel association test with multi-categorical outcomes (MiRKAT-MC) that is versatile to deal with both nominal and ordinal outcomes for independent and clustered data and incorporates multiple ecological distances to allow for different association patterns between outcomes and microbiome compositions to be incorporated.Advocating for prehabilitation for patients undergoing gynecology-oncology surgery.
01 Apr 2022 - Ejso
In this article , a multimodal program combining exercise, nutrition and psychological interventions to strengthen patients physically and mentally before surgery by addressing modifiable risk factors during the preoperative period is proposed.Swiss Cheese Model of food safety incidents: Preventing foodborne illness through multiple layers of defence
01 Apr 2022 - Food Control
In this paper , a defence model based on the Swiss Cheese Model, HACCP and the Five Keys to Safer Food was proposed to prevent foodborne illness in restaurants. But, the model was not tested with a Partial Least Square Structural Equation Model.Retrotransposon Insertion Polymorphisms (RIPs) in Pig Coat Color Candidate Genes
01 Apr 2022 - Animals
42 RIPs were revealed in 20 coat color genes in pigs, and some RIPs may be useful in distinguishing different breeds, as well as being associated with breed differences.A simplified modal analysis of a single lap bonded joint using the macro-element technique
01 Apr 2022 - International Journal of Solids and Structures
In this article , a simple and quick numerical tool dedicated to the modal analysis of single lap-bonded joints with balanced and unbalanced adherends with various boundary conditions is presented.Laparoscopic versus open pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: study protocol for a multicentre randomised controlled trial
01 Apr 2022 - BMJ Open
It is hypothesised that LPD is not inferior to OPD for the treatment of resectable PDAC, and this study is designed as a prospective, randomised controlled, parallel-group, open-label, multicentre noninferiority study.Computed Tomography Assessment of Tidal Lung Overinflation in Domestic Cats Undergoing Pressure-Controlled Mechanical Ventilation During General Anesthesia
01 Apr 2022 - Frontiers in Veterinary Science
Ventilation with 5 and 7 cmH2O of airway pressure prevents overinflation in healthy cats with highly compliant chest walls, despite presenting acidemia by respiratory acidosis.Abundant Species Diversity and Essential Functions of Bacterial Communities Associated with Dinoflagellates as Revealed from Metabarcoding Sequencing for Laboratory-Raised Clonal Cultures
01 Apr 2022 - International Journal of Environmental Research and Public Health
In this paper , the authors characterized the bacterial community associated with laboratory cultures of 144 harmful algal strains, including 130 dinoflagellates and 14 non-dinoflagllates, via high-throughput sequencing for 16S rRNA gene amplicons.Iron oxide nanoparticles oxidize transformed RAW 264.7 macrophages into foam cells: Impact of pulmonary surfactant component dipalmitoylphosphatidylcholine.
01 Apr 2022 - Chemosphere
In this article , the interaction of inhaled IONPs and pulmonary surfactant (PS) was investigated at the molecular level, which is helpful for further understanding the adverse effects of IONS.Formulation of Glycyrrhizic Acid-based Nanocomplexes for Enhanced Anti-cancer and Anti-inflammatory Effects of Curcumin
01 Apr 2022 - Biotechnology and Bioprocess Engineering
In this paper , nanocomplexes composed of glycyrrhizic acid (GA) derived from the root of the licorice plant were formulated for the delivery of curcumin (CUR).Role of B-site disorder in the properties of lead-free Na0.5Bi0.5(Mg1/3Nb2/3)O3 ceramic: A possible electrocaloric material with low leakage current
01 Apr 2022 - Journal of Physics and Chemistry of Solids
In this paper , a lead-free Na.5Bi0.5TiO3-based ferroelectric material is selected for this particular application, which shows a frequency-independent high ferro-paraelectric transition temperature (460 °C) with a slim polarization vs electric field loop.Therapeutic potential of viral vectors that express venom peptides for neurological diseases
01 Apr 2022 - Medical Hypotheses
The venoms of arachnids, cone snails, and snakes consist of many peptides that have many physiological activities, e.g., modulation of ion channels as discussed by the authors .A subject-specific FEM to predict deep tissue mechanical stresses when supine: Development of efficient contact interfaces using Shared Topology.
01 Apr 2022 - Journal of Biomechanics
In this article , the authors proposed a method for the development of efficient contact definitions using shared topology, which resulted in a 37% reduction in solution time compared to an equivalent FEM defined with Bonded contact.ANN modeling of the significance of constraints in turning superalloys using coated PCBN tools
01 Apr 2022 - Materials Today: Proceedings
In this paper , the output responses of the machining of the superalloy Ti6Al4V using TiN coated PCN insert by varying the three processing constraints in five levels via the L25 Taguchi array were analyzed.Effects of soaking and germination on deoxynivalenol content, nutrition and functional quality of Fusarium naturally contaminated wheat
01 Apr 2022
In this paper , the authors investigated the content of deoxynivalenol (DON), sugars, proteins, phenolics, amino acids, the antioxidant capacity and antioxidant enzymes activities of Fusarium naturally contaminated wheat (FCW) during soaking and germination.Heterologous expression and characterization of a thermoalkaliphilic SAM-synthetase from giant leucaena (Leucaena leucocephala subsp glabrata).
01 Apr 2022 - Plant Physiology and Biochemistry
In this paper , the cDNA encoding S-adenosylmethionine (SAM) synthetase was isolated from giant leucaena root tissue mRNA, which was used to obtain the transcript sequence and clone into the T7-expression vector pEt14b.The power of alternative suppliers in the automotive industry – A matter of innovation?
01 Apr 2022 - Industrial Marketing Management
In this article , a two-way analysis of variance is performed to identify the cost-benefit optimum for the number of suppliers and analyzes the moderating role of the degree of innovation.Napoleonic Commemoration on the Operatic Stage
01 Apr 2022 - French Historical Studies
La reine de Chypre, a five-act grand opera by Fromental Halévy and Henri de Saint-Georges, was performed at the Opéra de Paris in 1841 as discussed by the authors .Role of mTOR through Autophagy in Esophageal Cancer Stemness
01 Apr 2022 - Cancers
It is demonstrated, using EC cell lines and patient-derived organoids, that the hypoxia-responding mammalian target of rapamycin (mTOR) can suppress autophagy and stemness of esophageal CSCs.Micro reactors for measurement and analysis of thermochemical gas-solid reactions
01 Apr 2022 - Resources chemicals and materials
A broad classification of microreactors used for thermal analysis of gas-solid reactions is presented in this paper , where the authors provide general guidance for the selection and operation of the microreactor to satisfy one's practical specific needs.Unraveling inhibitory effects of Alpinia officinarum Hance and curcumin on methylimidazole and acrylamide in cookies and possible pathways revealed by electron paramagnetic resonance.
01 Apr 2022 - Food Chemistry
In this article , the synchronous mitigative effects of Alpinia officinarum Hance (AOH) and curcumin on the generation of methylimidazole and acrylamide in cookies were investigated.Derivation And Validation Of A New Formula For Plasma Osmolality Estimation.
01 Apr 2022 - Clinical biochemistry
In this article , a multivariate lineal regression was carried out, considering sodium and potassium as separated variables and as unique variable, to develop a new equation for plasma osmolality calculation and assess the new equation in a sample of healthy individuals.ECG Arrhythmia Classification Based on Wavelet Packet Transform and Sparse Non-Negative Matrix Factorization
01 Apr 2022 - Journal of Iranian Association of Electrical and Electronics Engineers
ECG Arrhythmia Classification based on Wavelet Packet Transform and Sparse Non-Negative Matrix Factorization is described in this article , where the authors use a sparse non-negative matrix factorization.Observational features of thin accretion disks around traversable wormholes
01 Apr 2022 - Journal of Physics: Conference Series
In this article , the authors investigate the appearance of qualitatively new observational features of accretion disk images around compact objects, focusing on a particular class of traversable wormholes, possessing a photon sphere.Jin Ping Mei: A Story of Guanxi
01 Apr 2022 - Folklore
Wang et al. as discussed by the authors interpreted Jin Ping Mei from the perspective of human relationships, and the concept of guanxi, the ubiquitous and quotidian social network in China, better describes the specific human relationships in this fiction.Optimization of 1U nanosatellite on the basis of strength and weight using different Materials: A numerical approach
01 Apr 2022 - Materials Today: Proceedings
In this paper , the feasibility of using composites as an alternative to metallic alloys on the basis of stress and deformation value was analyzed and the material HTM143/M55J shown major improvement in the weight and strength ratio as compared to other two materials.gLAB hands-on education on satellite navigation
01 Apr 2022
The results illustrate some examples of how the PVT can be enhanced or deteriorated when using different processing strategies or propagation effects present in the GNSS signals traversing the atmosphere, among others.Mid-Term Outcome of Lobar Lung Transplantation: Hamburg Experience
01 Apr 2022 - Journal of Heart and Lung Transplantation
In this article , the authors compared early complications, long-term lung function and survival with conventional bilateral lung transplantation (CLuTx) with a mean waiting time of 241±210 days, which was comparable with CLuTx (p=0.333).Study of the Influence of the Layer Thickness of Composite Coatings Based on Barium Sulphate on the Attenuation of X-Ray Radiation
01 Apr 2022 - Медицинская радиология и радиационная безопасность
In this article , the authors defined the regularities in X-ray radiation attenuation, which characterize composite coatings based on barium sulfate and the aqueous alkaline sodium silicate solution, depending on the thickness of the layer of such coatings deposition.Acute Pericarditis Presenting Concurrently with Acute Cellular Rejection in a Lung Transplant Recipient
01 Apr 2022 - Journal of Heart and Lung Transplantation
In this article , the authors presented a case of a patient 12 years out from lung transplant who presented with findings compatible with acute pericarditis, ultimately diagnosed with acute cellular rejection (ACR).Radiology Review.
01 Apr 2022 - Journal of Knee Surgery
In this article , the authors discuss mechanisms of injury and cartilage imaging, both of which can easily be applied to the knee joint and discuss common injuries patterns such as bone contusions following anterior cruciate ligament failure as well as more rare entities like friction syndromes and dislocation of knee joint.Impact of the pandemic covid-19 on digestive endoscopic activity
01 Apr 2022 - Endoscopy
The COVID-19 pandemic had a significant impact on endoscopy services, its staff and especially on patients following the reduction and limitation of endoscope indications and procedures in Morocco.A study of T/NK cell distribution in HIV positive adults by flow cytometry
01 Apr 2022 - International journal of clinical and diagnostic pathology
It is revealed that activation levels of NK cells are elevated and coordinated in HIV infections and are associated with reduced CD4+ T cell percentages and higher viral loads, in a HIV infection.Structural degradation behavior of Mg2-Pr Ni4 upon hydrogenation
01 Apr 2022 - Journal of Alloys and Compounds
In this paper , the hydrogenation properties of Mg2-xPrxNi4 (x = 1.0, 1.2 and 1.4) and their structural degradation (amorphization) upon hydrogenation were investigated using in-situ X-ray diffraction.A Positive CDC T-cell Crossmatch is Strongly Associated with Allograft Loss and Early Rejection in Pediatric Heart Transplant Recipients
01 Apr 2022 - Journal of Heart and Lung Transplantation
A recent multi-center study (CTOT-04) reported similar first year outcomes in children with CDC T-cell crossmatch (XM) + and XM- heart transplant (HT) but was underpowered and had only 11 children in the CDC+ HT group as discussed by the authors .Clinical applications of artificial intelligence in gastroenterology: excitement and evidence.
01 Apr 2022 - Gastroenterology
In this paper , Deep Blue, the chess-playing computer, defeated Gary Kasparov, the world champion, in 1997, this was seen as a significant milestone in the development of artificial intelligence (AI).Impact of Hot-Carrier Degradation Due to Moisture Diffusion Based on 0.153um CMOS
01 Apr 2022 - Journal of Physics: Conference Series
In this article , the authors investigated the impact of moisture diffusion on hot-carrier-induced degradation of MOSFETs under different conditions, including HDP thickness reduction, alloy after HDP, deposition of SRO layer before HDP and material of TEOS.Trending questions
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